Secrets of a Secretase
نویسندگان
چکیده
منابع مشابه
Secrets of a Secretase N-Cadherin Proteolysis Regulates CBP Function
Presenilin (PS-1) is part of the protease gamma-secretase that cleaves the membrane proteins APP and Notch. In this issue of Cell, Marambaud et al. report that PS-1 cleaves the cell adhesion molecule N-cadherin, releasing a C-terminal fragment that promotes degradation of the transcriptional coactivator CBP. Mutations in PS-1 associated with Alzheimer's disease interfere with CBP proteolysis, l...
متن کاملStructure of nicastrin unveils secrets of γ-secretase.
Despite afflicting tens of millions worldwide, Alzheimer’s disease (AD) remains a devastating brain-destroying malady with no effective treatment or cure. A central hallmark of AD is the deposition of amyloid plaques in the brain. These plaques are primarily composed of the amyloid β-peptide (Aβ), a byproduct of proteolytic processing of the amyloid precursor protein (APP) within its transmembr...
متن کاملA Market for Secrets
We propose an electronic market system for private data that guarantees levels of privacy, anonymity and control to individuals while maintaining the ability of other entities to mine their information and automatically pay individuals for their data. We also describe a novel procedure that allows data miners to anonymously contact the creators of the information in case their profiles are need...
متن کاملA spinner's secrets.
Slinky These motifs are rich in the amino acids glycine and proline and help give silks their stretchiness. Zipper Other glycine-rich regions zip together, forming helixes that confer flexibility. Lego These regions contain repeating alanines that lock together, adding toughness. A living textile factory The golden orb-weaver has seven kinds of silk glands (distinguished left, by color), with e...
متن کاملSecrets of Light in Traditional Houses of Iran
In addition to attention to natural light as a renewable, costless and environment-friendly source of energy in the late 20th century, numerous studies have been conducted into the effect of natural light on human being’s soul and body and all such studies reiterate the undeniable role of natural lighting on people’s behavior, attitudes, and efficiency. However, in spite of the awareness of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00686-x